Just distort the map so it fits

(/s)

Or just rotate it to direction of travel if it’s for a route. After a turn is shown it would switch to forward is up.

Well, in this case it was a curvy but predictable line, namely a river.

As an Egyptian, I think this would be a great map format for our country.

Though the delta would pose an issue, the nile also goes diagonal in the south, so it’d have to switch from north-up in the north to nortwest-up in the south which would probably be jarring