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7 points
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Changing the default will break the workflows of tens of thousands in the business industry

Scientists should be using something like MATLAB, not Excel.

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3 points

They’re not doing their analysis in Excel. MATLAB solves no problems here?

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6 points

Matlab is used, if at all, by physicists.

We’re talking about molecular biologists.

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3 points

You could make a new filetype, default new versions to it, & not break compatibility. Wouldn’t do anything for existing workbooks, and keep xlsx an option, but “it would break compatibility” is not a be-all end-all argument against this.

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