Star Trek actors are the most robust actors. They’re everywhere. I watched all of Boston Legal without realizing it wasn’t Star Trek. Our boy Frakes plays adult Finn in the adventure time episode Puoy, George plays Ricardio. You can’t escape it. Star Trek encompasses all.
Edit: sort of unnecessary edit but when I use actors here it is gender neutral.
Ensign Ro and old Jake are both in Half-Life 2, those voices are ingrained in my memory so I instantly recognized them when i watched the show.
Chris Judge from Stargate did the same. That dude is in a lot of video games.
Kate Mulgrew was a very distinctive voice. I heard it right away in Dragon Age Origin.
Patrick Stewart also has a great voice in Elder Scrolls Oblivion.
The first person from Trek I remember hearing in a game was Leonard Nimoy in Civilization.
I definitely remember recognizing Frakes, Dorn, and de Lancie while playing through the War of the Chosen expansion for XCOM2. Also René Auberjonois on a few of the Uncharted games as well.
Don’t forget Marina Sirtis and Denise Crosby in XCom 2! It was quite the TNG reunion.