Closest thing I use to a professional app is DaVinci Resolve Studio on a distribution that is not officially supported by Blackmagic. Not only does Resolve Studio work perfectly, I am able to use Blackmagic hardware (Intensity Pro 4k, Speed Editor) without having to mess around with settings, config files, permissions, packages, etc.

The caveat here is the initial setup: I use an AMD GPU, and it’s a bit of a pain to get the free and licensed versions of Resolve working with those under Linux. However, once that’s out of the way, it’s completely seamless.

As for CAD…yeah that’s where everything falls over. There are tons of FOSS alternatives out there but I have yet to see any of them in a professional setting. Even Fusion360 is hit or miss under Wine, I spun up a Windows VM just to use that for my 3D printer tinkering.