It depends on the VM, but some of them have working graphics hardware acceleration. Virtualbox should be relatively easy to set up with modern Windows guests, but isn’t free for commercial use. qemu/kvm is free for all uses, but may require some tinkering to get everything to work. qemu also supports video passthrough—using the VM to drive a second video card installed in your machine—which some gamer types prefer.

I don’t have experience with it, but I’m sure it’s possible to pass the GPU control to the VM, I don’t know how well this sort of thing works.

I think in general, VMWare is the best at working for Windows images.

nyan answered your question, I just want to add that older photoshop allegedly runs well in wine and for me personally i’ve had a lot of success with photopea although I’m a terrible example because I don’t do much with it.