Sorta. By then, the rules on thinking machines have been somewhat relaxed, but people still don’t like being around computers. There are machines that can navigate FTL safely without relying on spice. The Bene Gesserit are still dependent on it, though, and they don’t like how it binds them to either the Tleilaxu or surviving sandworms.
Doesn’t invalidate the point made: at some point, a previously irreplaceable resource was synthesized and mass produced.
I still have to find the time and motivation to read the entire Dune but if at some point they start mass producing the stuff that literally held them prisoners, as there is no going back once spice is first taken, they are literally a civilization of drug addicts, willingly.