Fun fact: octopuses* respond to MDMA, and become social and cuddly. https://www.pbs.org/newshour/science/scientists-gave-octopuses-some-molly-heres-what-happened

I seem to recall a similar story where drug exposure reversed the octopus’s usual behavior of simply waiting for death after mating, but I couldn’t find a reference from a quick search so perhaps I am misremembering this story, about the biological mechanisms behind that behavior: https://www.sciencealert.com/scientists-close-in-on-why-octopuses-tragically-destroy-themselves-after-mating