Assembly effectively is coding in binary. Been a long time since I’ve looked at it, but you’d basically just be recreating the basic assembly commands anyway.

I guess you could try flipping individual transistors with a magnet or an electron gun or something if you really want to make things difficult.

If you actually want to one-up assembly coders, then you can try designing your own processor on breadboard and writing your own machine code. Not a lot of easy ways to get into that, but there’s a couple of turbo dorks on YouTube. Or you could just try reading the RISC-V specification.

But even then, you’re following in someone else’s tracks. I’ve never seen someone try silicon micro-lithography in the home lab, so there’s an idea. Or you could always try to beat the big corps to the punch on quantum computing.