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22 points

The first part of the joke is that the image shows “Mitosis” - a process in which a cell splits in two. The word sounds like “my toe, sis”.

The second part of the joke is that the Mitosis diagram vaguely resembles “Loss”, a webcomic. https://amp.knowyourmeme.com/memes/loss

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1 point

The first part of the joke is the type that people like me will never understand without someone explaining. I can tell it’s mitosis but I can’t tell that’s what fills the gap. It just never comes to me on my own.

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