22 points
The first part of the joke is that the image shows “Mitosis” - a process in which a cell splits in two. The word sounds like “my toe, sis”.
The second part of the joke is that the Mitosis diagram vaguely resembles “Loss”, a webcomic. https://amp.knowyourmeme.com/memes/loss
7 points
also STEP-sis
1 point