The thing is, in Enterprise people were supposed to be savage mavericks. In DS9, they were supposed to be advanced.
Archer withheld a cure for an entire species because Phlox convinced him it was the natural course of things. (Valakians) Janeway goes back in time to get her ship home with more crew alive, altering history in who knows what ways for the entire galaxy.
I hate that Enterprise episode because it is such an edge case for the Prime Directive, and humanity hasn’t even adopted it yet.
Even if the species didn’t develop warp drive, they have had contact with other species that did. This isn’t a pure, uncontaminated species that needs to be protected. Hell, I think that this species even contacts the Enterprise.
And this seems to be a trivial enough cure that this species is going to find another species to cure them. If Phlox can develop a cure in weeks on a spaceship, this seems to be trivial work for space faring civilizations.
If we consider Sisko’s personal vendetta a bad thing that makes us question his authority to lead, I don’t understand how we excuse Janeway and the time travel stuff she pulled to get Voyager home–her actions had exponentially more butterfly effect consequences than Sisko could ever dream of.
I feel like Janeway was justified if just due to the fact that the Equinox was a Starfleet crew that were breaking major Federation law. If any ship in the Delta Quadrant had the right to punish the crew of the Equinox, it was Voyager.
