It doesn’t look like the meme is mocking his culture, only his religion. On top of that, it appears to be calling out his hypocrisy when it comes to secular American politics. So I don’t really see how an Atheist Jew would take offense to this meme that’s mocking a religion they don’t follow, as well as his theocratic-inspired American legislation efforts.
I’m not even an atheist, I’m Catholic. I just saw this meme and thought it was funny because I too think Ben Shapiro’s religious dogma is both bullshit and at odds with half the shit he says. If he was a Christian and these “bigots” made fun of his crucifix instead of yarmulke it wouldn’t really bother me.