If it’s truly meant as a simulation, then intervening in any way would go against the purpose of the simulation.
Just think about how we run our simulations. We give the computer parameters about the “real” world because we’re interested in the results. If our entire world is a simulation, amongst other simulations, then intervening would ruin the simulation.
Checkpointing interesting points in simulations and rerunning with modified parameters happens literally all the time
Especially weather / climate / geology and medicine
They’re re-run, though. You don’t change the parameters in the middle of the simulation. That goes against the point of simulating something.
You don’t rerun everything from scratch. Especially weather simulations can be checkpointed at places you have high certainty, and keep running forks after that point with different parameters. This is extremely common with for example trying to predict wind patterns during forest fires, you simulate multiple branches of possible developments in wind direction, humidity, temperature, etc. If the parameters you test don’t cover every scenario that is plausible you might sometimes engineer it into the simulation just to see the worst case scenario, for example.
And in medicine, especially computational biochemistry you modify damn near everything