Only real issues that I’ve seen lately are upstream with QEMU, which will probably be sorted soon, if they’re not already. I’m absolutely amazed at how well they implemented the x86_64 compatibility.
If found that a few open source apps that are stubbornly Intel only binaries can be compiled as universal apps in Xcode. For example OpenEmu.
Any issues running those with Rosetta? I run x86 VMs regularly without issue.
It was about 50/50, but fortunately everything that didn’t work had upgrades to universal or Apple silicon available. I imagine things were rougher for the early adopters. What surprised me the most was being able to run Windows Steam via Whisky with very little drama.