I don’t think I can recall something truly novel since I think we’ve pretty much gone past the point of novel concepts in the majority of genres, but there have definitely been standouts in certain genres over the years.
In the deck building and rogue like genre we’ve seen Balatro, the poker based game. In the retro inspired games genre, we’ve got Corn Kidz 64, a shorter game that controls and looks like an N64 title.
Totally depends on the genre, though.