Well, a nuke is a sphere of c4 wrappy around a couple of pieces of plutonium, so if we’re not to hung up on the nuclear explosion part then yes.
Wait, if that’s the case why does it take massive teams of scientists to develop a nuke? I could duck tape some plutonium to a brick of C4 if I didn’t care about getting cancer.
Any existing nuclear weapon would work for that, just drop it on him without detonating it.