A team led by famed Harvard Medical School anti-aging researcher David Sinclair has just published a paper that shows a mix of chemicals are capable of reversing cellular aging…
and surely everyone will benefit from this right? not just the rich? right?
It’s Sinclair, stuff around him always gets overly-sensationalized, but skimming though the actual paper… damn, it looks surprisingly promising.
I look forward to having a class of rich people who will never die with the rest of us being considered expendable /s
Remember not aging doesn’t necessarily mean immortal.
Great, they’ll live to see the consequences of climate change and slowly die anyway
They will move to subterranean refuges and keep their everlasting bodies connected to the metaverse.
So… this is what hell was referring to all along?
- evil people: check
- underground: check
- everlasting: check
metaversetorment: check
Abstract
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals can restore youthful DNA methylation patterns, transcript profiles, and tissue function, without erasing cellular identity, a process that requires active DNA demethylation. To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, we developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay. We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.