Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have developed

6 points

Notably they trialled first for coeliac autoimmune, but it’ll be 2024 before phase 2 results are out for that. About 10 years back there was a similar vaccine which also passed phase 1 trials but failed at phase 2. Phase 1 is basically testing that the vaccine does no harm in small groups and it is phase 2 where they measure if it is actually efficacious and to what level. If it passes phase 2, then get your hopes up.

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2 points

I work in clinical (and preclinical) trials. And I have celiac disease. I’m hopeful but not optimistic that I’ll be able to eat pasta within the next decade.

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2 points

Hopeing there was stem cells used in the research for no particular reason.

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13 points

Yeah, sure 🙄

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27 points

I have MS, I’ll go wild once I hear it’s approved. Until then I’ll save my energy.

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59 points

I will click on this headline when the link is to Nature or Scientific American or the Mayo Clinic. Thank you very much.

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19 points

The article has the link to the original paper published in Nature Biomedical engineering at the bottom.

https://www.nature.com/articles/s41551-023-01086-2

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34 points
*

Thanks!

Hm, well the full paper is behind a subscription wall but the abstract sounds much more modest:

Our findings show that pGal–antigen therapy invokes mechanisms of immune tolerance to resolve antigen-specific inflammatory T-cell responses and suggest that the therapy may be applicable across autoimmune diseases.

“May be applicable” —> “can completely reverse” ???

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-1 points

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