The fact that these are supposed to be cultural categories and it doesn’t distinguish Appalachia is enough for me to discount this as total nonsense.
Personally I think this map is far better at mapping the cultures of the US (source: Monsieur Z “Utahism”)
The people who made this do not understand American cultural regions. The top level general ones are pretty well known. North East, Mid East, South East, Appalachia, Mid West, Great Plains, Bible Belt, Rockies, South West, SoCal, Valley, North West.
If you want to drill down that’s fine but the borders here make no sense at all.
The “interior” region especially makes no sense. Colorado, New Mexico, Utah, Nevada, North Dakota? Pretty much all of those places have wildly different culture from one another.