With all the hormones and whatnot inside. Dopamine, adrenaline, melatonin, whatever. Also, there’s this Hunter S. Thompson bit on the… pineal gland?
If it had an effect on you, wouldn’t it be a really messed up high, all over the place? With uppers, downers etc mixed? (Not including the emotional implications of eating raw human brains.)
That’s how you become a Wendigo.
Even if it was legal and ethical, don’t eat far-left’s. You’ll be so woke you will regret it.
It’s a good way to get prion disease for sure.
Why would that be likely? Wouldn’t that only be the case of the brain you are eating already has it?
For whatever reason prion disease has a chance to spontaneously occur when mammals cannibalize. Especially if they are obligate herbivores. Prion disease was originally discovered in cows transmitting it to humans due to some particularly sick fuck running a slaughter factory thinking it would be a good idea to put cow meat scraps back in their feed soylent green style.
no your stomach acid would denature most of the proteins, then they’d be conjugated at the liver so whatever goes in will be transformed by what comes out. A lot of those hormones are tightly regulated so I’m thinking even if they make it into circulation they’d be eliminated fairly quickly. Only exception would be if they’re acid stable, not impacted on their way through the gut/metabolised by microbiota, absorbed in tact and still active after the first pass effect. Also theres enzymes like trypsin in your stomach that are specifically for degrading proteins so I doubt it would make you anything other than a canibal.
The liver “conjugates”/metabolises a bunch of stuff, its been almost a decade since I studied this stuff but bassically it will remove or add functional groups on/off a given compound. Most of what you eat heads straight to the liver for “processing” where food (and orally administered drugs) get altered prior to circulation. Its part of the first pass effect.
you’re mostly right, however trypsin is produced in the pancreas and excreted into the duodenum, so not in the stomach. I think maybe you’re thinking of pepsin?
Ya it was the first one to pop into my head as an example, the main point is anything active would be neutralized one way or another by the time it ended up in circulation.
It would still go through the liver for metabolism. The only thing “boofing” effectively does is skip the stomach part of the digestive process. To take up anything from the digestive tract, it gets transported through the intestinal lumen and into the mesenteric and hepatic portal system. The liver filters everything that gets into the blood from the gut before it goes into the inferior vena cava and into the rest of the circulatory system.
Correction to clarify: the lower gut/colon mostly only takes up water and certain vitamins that are released by gut bacteria, and very small molecules like ethanol can sometimes get through as well. The very lowest part of the colon does have a vascular supply that can bypass the liver, and there are some medications designed to take advantage of the select receptors and transporters down there. However, neurotransmitters and peptide hormones (which is what OP was asking about) would likely not get taken up until it was much higher up in the digestive tract, and at that point it would go through the hepatic portal system.
Thank you to those that corrected me. Intestines are actually fairly complicated.
I don’t think that’s correct.
Does rectal have first-pass effect? In general, drug absorption in the upper part of the rectum is transported to the liver via the portal system and thus undergoes first-pass metabolism, whereas drug absorption in the lower rectum is transported directly to the systemic circulation
Would smoking raw human brains make you high?
Wait no thermal degredation
Would nebulizing raw human brains make you high? Especially of I got a little brain-diffuser in the corner that just filled the room with the aroma
Having absolutely no formal knowledge, I doubt it. The brain afaik is mostly fat…We also evolved eating animals we hunted and we didn’t just eat the meat. We ate the organs, liver, brain, etc. The liver is really full of that stuff and doesn’t make us high.
Why would you think it’s appropriate to comment if you’re just guessing? This is not a question where random guessing is appropriate.
Your reasoning is correct in that we do eat brains, and of course they don’t get us high.
You’re wrong is the fact that brain is mostly fat. That’s incredibly misleading. The brain is entirely nervous tissue plus supporting things like vessels. It does contain lots of myelin which serves to insulate axons, since nervous tissue is electrical. Myelin happens to contain a lot of fatty acids, but it is in no sense “fat”.
