It depends on the goal of the base.

I’ve always wanted to do a fully automatic city block, where each block produces exactly one resource, but get bored before that happens.

I’m currently working through seablock, and that’s some crazy spaghetti. The limited space and the general lack of speed means that there is a lot of tearing down and optimizing my builds. In traditional Factorio resources and space is basically unlimited so optimization isn’t necessary, in seablock a clogged belt means the entire factory stops running. So now I’m focused on efficiency.

I only use a bus at the start for the mall and research. Once my first ore patches are dwindling I have transitioned to blocks by product as well as the mall. Ingredients in, products out. All by train.

Mine start as a bus and then evolve into city block, I rebuild after the first launch leaving the mall fed by the bus.

Nothing like a good old spaghetti Bolognese

In a non overhaul playthrough, I normally use a main bus until the first rocket, then transition to full LTN to scale up to 1k spm and beyond. In BA, I use mostly crawler bots then logistic bots since the thought of a main bus or a belt fed mall in BA terrifies me.