Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

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7 points

Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn’t know?

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7 points

ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth

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3 points

Like a lil cashew down there.

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20 points

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I’ll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I’m allowed to be a real human. Guess my brain will clean itself when I die.

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9 points

Be careful about assuming that your drugs are what they’re talking about. Yours sound like they’re balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.

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-3 points

you probably just need fresh nutrients

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16 points

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

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1 point

What about Benadryl?

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11 points

The hat man cleans your brain for you.

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5 points

Unknown, but it’s an anticholinergic, and those are associated with dementia.

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9 points

Alcohol and weed does the same thing, just because you are out. Doesn’t mean you are sleeping.

Good to see this common sense being confirmed

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1 point

I wouldn’t even call it common sense. I remember being taught like 20 years ago that we don’t even know for sure why we need to sleep (aside from the fact that we get tired and sleep is pretty good at helping with that).

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5 points

What about alcohol?

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3 points

Fucks you up

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2 points

Then gets you really sleepy

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-1 points

Being knocked out is not sleep.

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3 points

Suppresses dreams and dreams are apparently good and needed for a healthy brain.

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0 points

Se thing as any other substance

Weed too

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1 point

What about sniffing glue?

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0 points

That shit don’t last long enough?

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