Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.
This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid
Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn’t know?
ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth
I wonder if ketamine has the same effect, he asked apropos of nothing…
Actually maybe not? Iirc most “traditional” anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a “blink and you miss it” ordeal, your brain isn’t active enough to be aware that time has passed).
However, if I’m not mistaken, stuff like ketamine or nitrous don’t do that, and sedate you in a manner more similar to natural sleep.
Fuck.
Now what?
Plenty of things to try.
The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.
Apparently the water supply in my town is dosed with sleeping pills.
Honestly, it might be. When people pee, that toilet water goes somewhere.
